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Investigación de vangarda para o desenvolvemento sostible

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Investigación de vangarda para o desenvolvemento sostible

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2018

Vilanova, Guillermo; Burés, Miguel; Colominas-Ezponda, Ignasi; Gomez, Hector

Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis Journal Article

In: Journal of the Royal Society, Interface, vol. 15, no. 146, pp. 20180415, 2018, ISSN: 1742-5662.

Abstract | Links | BibTeX | Etiquetas: angiogenesis, Angiogenesis Inducing Agents, Biological, Cell Proliferation, Computer simulation, Disease Progression, Endothelial Cells, Endothelium, Extracellular Matrix, Humans, interstitial flow, mathematical modelling, Models, Neoplasms, Neovascularization, Oxygen, Pathologic, phase field, Vascular, Vascular Endothelial Growth Factor A

@article{vilanova_computational_2018,

title = {Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis},

author = {Guillermo Vilanova and Miguel Burés and Ignasi Colominas-Ezponda and Hector Gomez},

doi = {10.1098/rsif.2018.0415},

issn = {1742-5662},

year  = {2018},

date = {2018-09-01},

journal = {Journal of the Royal Society, Interface},

volume = {15},

number = {146},

pages = {20180415},

abstract = {Angiogenesis, the growth of capillaries from pre-existing ones, plays a key role in cancer progression. Tumours release tumour angiogenic factors (TAFs) into the extracellular matrix (ECM) that trigger angiogenesis once they reach the vasculature. The neovasculature provides nutrients and oxygen to the tumour. In the ECM, the interstitial fluid moves driven by pressure differences and may affect the distribution of tumour TAFs, and, in turn, tumour vascularization. In this work, we propose a hybrid mathematical model to investigate the influence of fluid flow in tumour angiogenesis. Our model shows the impact of interstitial flow in a time-evolving capillary network using a continuous approach. The flow model is coupled to a model of angiogenesis that includes tip endothelial cells, filopodia, capillaries and TAFs. The TAF transport equation considers not only diffusive mechanisms but also the convective transport produced by interstitial flow. Our simulations predict a significant alteration of the new vascular networks, which tend to grow more prominently against the flow. The model suggests that interstitial flow may produce increased tumour malignancies and hindered treatments.},

keywords = {angiogenesis, Angiogenesis Inducing Agents, Biological, Cell Proliferation, Computer simulation, Disease Progression, Endothelial Cells, Endothelium, Extracellular Matrix, Humans, interstitial flow, mathematical modelling, Models, Neoplasms, Neovascularization, Oxygen, Pathologic, phase field, Vascular, Vascular Endothelial Growth Factor A},

pubstate = {published},

tppubtype = {article}

}